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ABFM NEWS - Medicina Nuclear
Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM)
"Introduction Microparticles derived from denatured human serum albumin (DOTA-derivatized human serum albumin microspheres, or DOTA-HSAM) are attractive carriers of radionuclides for both therapeutic and diagnostic purposes. In this article, we describe a labeling procedure for diagnostic (Ga-68) and therapeutic (Y-90, Lu-177) radionuclides and report on the results of stability studies of these products. Methods DOTA-HSAM was labeled in 0.5 M ammonium acetate buffer, pH 5.0, containing 0.02 mg/ml detergent. After adding the radionuclide, the mixture was shaken for 15 min at 90°C. Labeling yields and in vitro stability were determined by thin-layer chromatography. For determination of the in vivo stability of Ga-68 and Y-90 DOTA-HSAM, the particles were injected intravenously in Wistar rats. Results Labeling yields up to 95% in the case of Ga-68 and Lu-177 were achieved. Ga-68-labeled DOTA-HSAM showed high in vitro and in vivo stability. The amount of particle-bound radioactivity of Lu-177 DOTA-HSAM declines slowly in a linear manner to approximately 72% after 13 days. For Y-90, the labeling yield decreased with increasing radioactivity level. We presume radiolysis as the reason for these findings. Conclusion The labeling of DOTA-HSAM with different radionuclides is easy to perform. The radiation-induced cleavage of the labeled chelator together with the rather short half-life of radioactivity fixation in vivo (3.7 days) is, in our opinion, opposed to therapeutic applications of DOTA-HSAM. On the other hand, the high stability of Ga-68 DOTA-HSAM makes them an attractive candidate for the measurement of regional perfusion by PET. Nuclear Medicine and Biology Volume 37, Issue 8, November 2010, Pages 861-867" [+ leia mais]
Fonte: Nuclear Medicine and Biology
Lista de recomendações do Exame PET/CT com 18F-FDG em Oncologia.
"Apresentamos uma lista de recomendações sobre a utilização de 18F-FDG PET em oncologia, no diagnóstico, estadiamento e detecção de recorrência ou progressão do câncer. Foi realizada pesquisa para identificar estudos controlados e revisões sistemáticas de literatura composta por estudos retrospectivos e prospectivos. As consequências e o impacto da 18F-FDG PET no manejo de pacientes oncológicos também foram avaliados. A 18F-FDG PET deve ser utilizada como ferramenta adicional aos métodos de imagem convencionais como tomografia computadorizada e ressonância magnética. Resultados positivos que sugiram alteração no manejo clínico devem ser confirmados por exame histopatológico. A 18F-FDG PET deve ser utilizada no manejo clínico apropriado para o diagnóstico de cânceres do sistema respiratório, cabeça e pescoço, sistema digestivo, mama, melanoma, órgão genitais, tireoide, sistema nervoso central, linfoma e tumor primário oculto. " [+ leia mais]
Colaborador: Laura Natal
Fonte: Radiologia Brasileira
Management of persons contaminated with radionuclides: NCRP report no. 161 (Volume 1)
This report is intended as an update and expansion of NCRP Report No. 65, Management of Persons Accidentally Contaminated with Radionuclides, which was published in 1980. NCRP Report 161 provides guidance to those who may be called to respond to radionuclide contamination incidents and is issued in two volumes. This review covers Volume 1 only. [+ leia mais]
Colaborador: Laura Natal Rodrigues
Fonte: Oxford Journals
Radiation exposure, protection and risk from nuclear medicine procedures
"It is no secret that the enthusiastic use of X-rays and radioactive materials in the early years following their discovery led to numerous biological adverse effects. Realisation of this cause-effect relationship sparked a keen interest in protection against the hazards associated with medical radiation exposure." [+ leia mais]
Colaborador: Rodrigo Biancardi
Fonte: Springer Link
The RPOP website has been updated as:
Spanish version of training material on Radiation Protection in Nuclear Medicine for FREE download [+ leia mais]
Fonte: IAEA
Design and performance of a respiratory amplitude gating device for PET/CT imaging
Purpose: Recently, the authors proposed a free-breathing amplitude gating (FBAG) technique for PET/CT scanners. [+ leia mais]
Fonte: Medical Physics
Joint ICRP/ICRU Publication on Adult Reference Computational Phantoms
"A joint ICRP/ICRU Publication on Adult Reference Computational Phantoms, ICRP Publication 110, has been published (see Editorial). Click here for more information on how to order this publication. " [+ leia mais]
Fonte: ICRU
XXV Congresso Brasileiro de Medicina Nuclear
"Entre 4 e 7 de setembro de 2010, em Belém do Pará, a Sociedade Brasileira de Biologia, Medicina Nuclear e Imagem Molecular (SBBMN) promove a vigésima quinta edição de seu congresso, realizado a cada dois anos nas mais diferentes cidades do país. Espera-se a participação de 500 profissionais da saúde de todo país, entre médicos nucleares e de outras especialidades, biomédicos, tecnólogos, biólogos, físicos, farmacêuticos, químicos e outros profissionais da saúde, que assistirão palestras, simpósios e mesas-redondas sobre pesquisas, avanços tecnológicos, radiofármacos, proteção radiológica, exame PET/CT, diagnóstico e tratamento de doenças através da Medicina Nuclear. Esta especialidade permite fazer diagnóstico e tratamento de diversas doenças, especialmente na Oncologia, na Cardiologia e na Neurologia. Por exemplo: é fundamental no diagnóstico de diferentes tipos de câncer, facilitando o acompanhamento e a evolução do paciente durante o tratamento. Informações pelo telefone (11) 3262-5438, pelo fax (11) 3284-5434, pelo e-mail sbbmn@sbbmn.org.br e no site www.sbbmn.org.br. " [+ leia mais]
Colaborador: Secretaria Geral da ABFM
Fonte: SBBMN
Control reglamentario de las fuentes de radiación
Normas de seguridad del OIEA para la protección de las personas y el medio ambiente [+ leia mais]
Colaborador: Laura Natal Rodrigues
Fonte: IAEA
Almacenamiento de desechos radiactivospara
Normas de seguridad del OIEA para la protección de las personas y el medio ambiente [+ leia mais]
Colaborador: Laura Natal Rodrigues
Fonte: IAEA
"Design and construction of a quality control phantom for SPECT and PET imaging"
In this article, the authors present a method for quickly and easily constructing test phantoms for PET and SPECT quality assurance. As a demonstration, they constructed a complex prototype test phantom, showing the strengths of the construction method. [+ leia mais]
Colaborador: Érika Yumi Watanabe
Radiation Dosimetry of 89Zr-Labeled Chimeric Monoclonal Antibody U36 as Used for Immuno-PET in Head and Neck Cancer Patients
Immuno-PET is an appealing concept in the detection of tumors and planning of antibody-based therapy. For this purpose, the long-lived positron emitter 89Zr (half-life, 78.4 h) recently became available. [+ leia mais]
Colaborador: Rodrigo Biancardi
Fonte: The Journal of Nuclear Medicine
Quality Assurance for SPECT Systems
Quality assurance (QA) is a crucial part of all aspects of nuclear medicine practice. The objective of this publication is to provide professionals in nuclear medicine centres with detailed quality control test procedures for the scintillation camera and computer system. [+ leia mais]
Fonte: IAEA
A robotic system for 18F-FMISO PET-guided intratumoral pO2 measurements.
An image-guided robotic system was used to measure the oxygen tension (pO2) in rodent tumor xenografts using interstitial probes guided by tumor hypoxia PET images [+ leia mais]
Colaborador: Cássio Vilela Komatsu.
Fonte: Medical Physics.
Review of the Linogram and Sinogram: An Easy Way to Detect Off-Peak Artifacts in Myocardial Perfusion SPECT.
The correct energy window setting and a stable photopeak position are crucial for good data acquisition. We report a patient whose myocardial perfusion SPECT images showed mildly irregular radiotracer uptake when the patient was prone but not when the patient was supine. [+ leia mais]
Colaborador: Rodrigo Biancardi.
Fonte: Journal of Nuclear Medicine Technology.
IOMP Science Committee Bibliographic database: Nuclear Medicine.
A set of references has been developed by the IOMP Science Committee covering the medical physics aspect of radiation therapy, medical imaging, nuclear medicine, and radiation safety. [+ leia mais]
Colaborador: Laura Natal Rodrigues.
Fonte: IOMP.
Quality Assurance for PET and PET/CT Systems.
This publication provides guidelines for the implementation of quality assurance and control programmes concerning the combined medical diagnostic modality of positron emission tomography (PET) and computed tomography (CT). [+ leia mais]
Colaborador: Laura Natal Rodrigues.
Fonte: AIEA.
Cyclotron Produced Radionuclides: Guidelines for Setting up a Facility.
"Technical Reports Series No. 471.
Cyclotrons are used for preparation of a wide variety of radionuclides that find application in single photon emission computed tomography (SPECT) as well as in positron emission tomography (PET). This publication gives comprehensive guidelines for the planning and decision making processes and design and implementation of a cyclotron based radionuclide production facility. It will enable Member States to plan such facilities in a cost effective manner." [+ leia mais]
Colaborador: Camila Pessoa de Sales.
Fonte: AIEA.
PET/CT: Training material developed in collaboration with...
"Training material developed in collaboration with World Health Organization (WHO) International Organization for Medical Physics (IOMP) World Federation of Nuclear Medicine and Biology (WFNMB)." [+ leia mais]
Colaborador: Camila Pessoa de Sales.
Fonte: AIEA.
A flexible multicamera visual-tracking system for detecting and correcting motion-induced artifacts in cardiac SPECT slices.
Patient motion is inevitable in SPECT and PET due to the lengthy period of time patients are imaged. The authors hypothesized that the use of external-tracking devices which provide additional information on patient motion independent of SPECT data could be employed to provide a more robust correction than obtainable from data-driven methods. [+ leia mais]
Colaborador: Rodrigo Biancardi.
Fonte: Medical Physics.
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